Samuel's biography can be found at Wikipedia which describes his education, service in the military in World War I, his patents, and his architectural career including the notable buildings he designed.
Samuel married Gertrude Elizabeth Long in 1925 and had one child:
Elizabeth Lincoln Otis (1930-2002) - married Merrill Everett Conaway (1929-2002)
"New York, Passenger Lists, 1820-1957," digital images, Ancestry.com (http://www.ancestry.com : accessed 16 November 2014), Samuel Otis, arrival 2 Nov 1929 aboard ship President Roosevelt
"United States World War II Draft Registration Cards, 1942," digital image, FamilySearch (http://www.familysearch.org : accessed 16 November 2014), Samuel Shackford Otis